CHKB

Across TCGA pan-cancer cohorts, CHKB mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CHKB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CHKB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHKB is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where CHKB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHKB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.538	<.001	11	view →
LSCC	Male	All	−0.347	<.001	8	view →
LUAD	All	II,III,IV	−0.183	<.001	8	view →
HNSC	All	All	−0.120	.009	6	view →
PDAC	All	All	+0.265	<.001	5	view →
OV	All	All	−0.335	.003	2	view →
CCRCC	All	II,III,IV	−0.104	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CHKB–COAD

Open the COAD breakdown →