CHKB

Across TCGA patient cohorts, CHKB RNA expression is significantly associated with the go_rna of many other GO terms, with 7,165 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible CHKB-associated GO terms across cancer lineages are Phosphatidylethanolamine biosynthetic process, Positive regulation of sphingolipid biosynthetic process, and Transcription-coupled nucleotide-excision repair. Each is linked with CHKB in more than 28 cancer types. Because this analysis shows association rather than direction, both CHKB-to-partner and partner-to-CHKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylethanolamine biosynthetic process grouped by CHKB-low versus CHKB-high in KIRC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKB→partner) and Y-score (partner→CHKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Phosphatidylethanolamine biosynthetic process →	+0.080	+1.141	<.001	<.001	3	29
KIRC	Positive regulation of sphingolipid biosynthetic process →	+0.070	+1.056	<.001	<.001	3	28
SCLC	Transcription-coupled nucleotide-excision repair →	+0.086	+0.716	.003	<.001	2	27
UCS	Regulation of telomere maintenance in response to DNA damage →	+0.055	+0.936	<.001	<.001	2	27
KIRC	Regulation of DNA strand elongation →	+0.059	+1.182	<.001	<.001	3	26
KIRC	Phosphatidylethanolamine metabolic process →	+0.063	+0.979	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,165 associations by consensus.

Phosphatidylethanolamine biosynthetic process by CHKB expression — KIRC

Explore this box plot interactively →