CHKB

Across TCGA cell cohorts, CHKB mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CHKB-associated genes across cancer lineages are ACER1, OR10H5, and C16orf82. Each is linked with CHKB in more than 1 cancer types. Because this analysis shows association rather than direction, both CHKB-to-partner and partner-to-CHKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by CHKB-low versus CHKB-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKB→partner) and Y-score (partner→CHKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACER1 →	+0.018	+4.977	.001	.007	3	1
SKIN	OR10H5 →	+0.019	+4.977	<.001	.007	3	1
SKIN	C16orf82 →	+0.016	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ACER1 by CHKB expression — SKIN

Explore this box plot interactively →