CHKA

Across TCGA pan-cancer cohorts, CHKA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHKA data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHKA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHKA expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and OV are the cancer types where CHKA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.517	0.737	.022	12	view →
LUAD	OS	Quartile	All	0.978	0.480	.010	11	view →
OV	DFS	Median	All	0.862	1.000	.037	4	view →
PDAC	DFS	Median	IV	0.741	0.205	.024	3	view →
GBM	DFS	Median	All	0.751	0.684	.031	2	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHKA–HNSC (DFS)

Open the HNSC breakdown →