CHKA

Across TCGA patient cohorts, CHKA RNA expression is significantly associated with the protein abundance of many other proteins, with 11,172 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHKA-associated proteins across cancer lineages are CSTA, TBC1D2, and JUNB. Each is linked with CHKA in more than 4 cancer types. Because this analysis shows association rather than direction, both CHKA-to-partner and partner-to-CHKA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHKA versus CSTA in HNSC, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKA→partner) and Y-score (partner→CHKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CSTA →	-0.996	-0.801	<.001	<.001	3	5
CCRCC	TBC1D2 →	-0.432	-0.469	.001	<.001	3	5
LSCC	JUNB →	-0.377	-0.468	<.001	<.001	3	4
HNSC	FNBP1L →	+0.337	+0.585	<.001	.001	3	4
LSCC	REEP4_S152 →	-0.397	-0.468	<.001	<.001	3	4
LSCC	RSF1 →	+0.414	+0.631	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,172 associations by consensus.

CHKA vs CSTA — HNSC

Explore this scatter interactively →