CHKA

Across TCGA patient cohorts, CHKA protein abundance is significantly associated with the RNA expression of many other genes, with 8,003 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CHKA-associated genes across cancer lineages are IGFBP4, HTR7, and STARD5. Each is linked with CHKA in more than 3 cancer types. Because this analysis shows association rather than direction, both CHKA-to-partner and partner-to-CHKA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHKA versus IGFBP4 in BRCA, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKA→partner) and Y-score (partner→CHKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGFBP4 →	-1.142	-0.326	<.001	<.001	3	4
GBM	HTR7 →	-0.590	-0.238	.002	.002	3	4
LSCC	STARD5 →	-0.738	-0.281	<.001	.001	3	4
OV	CTSO →	-0.831	-0.606	<.001	<.001	3	4
OV	CD2 →	-1.759	-0.610	<.001	<.001	3	4
OV	ICOS →	-1.094	-0.648	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,003 associations by consensus.

CHKA vs IGFBP4 — BRCA

Explore this scatter interactively →