CHKA

Across TCGA cell cohorts, CHKA RNA expression is significantly associated with the go_rna of many other GO terms, with 5,207 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CHKA-associated GO terms across cancer lineages are Lipid droplet disassembly, CDP-choline pathway, and Phosphatidylcholine biosynthetic process. Each is linked with CHKA in more than 15 cancer types. Because this analysis shows association rather than direction, both CHKA-to-partner and partner-to-CHKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lipid droplet disassembly grouped by CHKA-low versus CHKA-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHKA→partner) and Y-score (partner→CHKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Lipid droplet disassembly →	+0.306	+1.514	.001	.001	3	16
LUNG_NSCLC_LUSC	CDP-choline pathway →	+0.143	+1.122	.001	.001	3	12
LIVER	Phosphatidylcholine biosynthetic process →	+0.147	+1.640	.005	.001	3	11
BREAST	Establishment of epithelial cell apical/basal polarity →	-0.144	-0.978	.006	.002	3	11
BONE	CAAX-box protein processing →	+0.207	+1.408	<.001	.001	3	9
OVARY	Positive regulation of interleukin-17 production →	-0.167	-1.123	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,207 associations by consensus.

Lipid droplet disassembly by CHKA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →