CHIT1

Across TCGA patient cohorts, CHIT1 mutation is significantly associated with the RNA expression of many other genes, with 3,143 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHIT1-associated genes across cancer lineages are OR2D2, CCNQP2, and NPLP1. Each is linked with CHIT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHIT1-to-partner and partner-to-CHIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D2 grouped by CHIT1-low versus CHIT1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIT1→partner) and Y-score (partner→CHIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR2D2 →	+0.088	+4.276	<.001	.008	3	2
CESC	CCNQP2 →	+0.065	+4.601	.001	.004	3	2
COAD	NPLP1 →	+0.110	+3.343	.001	.007	3	2
COAD	LINC01866 →	+0.432	+4.810	<.001	<.001	3	2
COAD	RNU2-24P →	+0.296	+3.279	.002	.002	3	2
COAD	RNU6-182P →	+0.505	+3.061	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,143 associations by consensus.

OR2D2 by CHIT1 expression — CESC

Explore this box plot interactively →