CHIT1

Across TCGA patient cohorts, CHIT1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHIT1-associated genes across cancer lineages are Ku80, ATM, and eEF2. Each is linked with CHIT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHIT1-to-partner and partner-to-CHIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by CHIT1-low versus CHIT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIT1→partner) and Y-score (partner→CHIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.323	+3.013	<.001	<.001	3	3
UCEC	ATM →	-0.560	-3.156	.002	.018	3	3
UCEC	eEF2 →	+0.413	+3.169	.005	.018	3	2
UCEC	mTOR_pS2448 →	-0.198	-2.321	.001	.006	3	2
UCEC	S6_pS240_S244 →	+0.345	+3.321	.039	.010	3	2
UCEC	Smad3 →	+0.132	+1.700	.034	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Ku80 by CHIT1 expression — UCEC

Explore this box plot interactively →