CHIT1

Across TCGA cell cohorts, CHIT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,748 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CHIT1-associated GO terms across cancer lineages are Polysaccharide digestion, Regulation of neurotrophin production, and Negative regulation of glutamate secretion. Each is linked with CHIT1 in more than 11 cancer types. Because this analysis shows association rather than direction, both CHIT1-to-partner and partner-to-CHIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Polysaccharide digestion grouped by CHIT1-low versus CHIT1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIT1→partner) and Y-score (partner→CHIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Polysaccharide digestion →	+1.243	+1.590	<.001	<.001	3	12
SOFT_TISSUE	Regulation of neurotrophin production →	+1.038	+0.173	<.001	.006	3	10
KIDNEY	Negative regulation of glutamate secretion →	+1.202	+0.171	.002	.007	3	7
SOFT_TISSUE	G protein-coupled purinergic nucleotide receptor signaling pathway →	+1.138	+0.194	<.001	.007	3	6
LUNG_SCLC	Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.111	+0.205	<.001	<.001	2	7
SOFT_TISSUE	Protein localization to cytoplasmic stress granule →	+0.076	+0.203	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,748 associations by consensus.

Polysaccharide digestion by CHIT1 expression — BLOOD_Myeloma

Explore this box plot interactively →