CHIT1

Across TCGA cell cohorts, CHIT1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHIT1-associated genes across cancer lineages are CSN2, SPRR2B, and LILRA1. Each is linked with CHIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHIT1-to-partner and partner-to-CHIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by CHIT1-low versus CHIT1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIT1→partner) and Y-score (partner→CHIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CSN2 →	+0.022	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPRR2B →	+0.044	+4.887	<.001	.009	3	1
LARGE_INTESTINE	LILRA1 →	+0.013	+4.095	.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.178	+4.273	<.001	.006	3	1
BLOOD_Leukemia	LUZP4 →	+0.455	+4.060	<.001	.003	3	1
BLOOD_Leukemia	MAGEA9 →	+0.161	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

CSN2 by CHIT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →