CHIC2

Across TCGA patient cohorts, CHIC2 protein abundance is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHIC2-associated genes across cancer lineages are SLC41A3, PLEKHH2, and XKR8. Each is linked with CHIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHIC2-to-partner and partner-to-CHIC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHIC2 versus SLC41A3 in UCEC, with a Pearson correlation of -0.90.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHIC2→partner) and Y-score (partner→CHIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SLC41A3 →	-0.597	-0.509	.009	.003	3	1
UCEC	PLEKHH2 →	-2.054	-0.509	.005	.003	3	1
UCEC	XKR8 →	-0.600	-0.509	.005	.003	3	1
UCEC	ALDH1A3 →	-1.734	-0.509	.004	.003	3	1
UCEC	RNU6-621P →	-1.279	-0.509	.004	.003	3	1
UCEC	TRBJ2-7 →	-3.310	-0.509	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

CHIC2 vs SLC41A3 — UCEC

Explore this scatter interactively →