Across TCGA pan-cancer cohorts, CHIC1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CHIC1 data layer compared with 20 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHIC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHIC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
HNSC, LUAD, and COAD are the cancer types where CHIC1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.