CHI3L1

Across TCGA pan-cancer cohorts, CHI3L1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CHI3L1 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CHI3L1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CHI3L1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where CHI3L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.780	1.000	.014	24	view →
PDAC	OS	Median	III,IV	0.347	0.829	.006	22	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	20	view →
LSCC	DFS	Quartile	III,IV	1.000	0.511	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CHI3L1–LUAD (OS)

Open the LUAD breakdown →