CHI3L1

Across TCGA patient cohorts, CHI3L1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHI3L1-associated genes across cancer lineages are mTOR, PDCD4, and ATM. Each is linked with CHI3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHI3L1-to-partner and partner-to-CHI3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by CHI3L1-low versus CHI3L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHI3L1→partner) and Y-score (partner→CHI3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.191	-2.321	.001	.033	3	2
UCEC	PDCD4 →	-0.420	-1.874	.015	.049	3	2
UCEC	ATM →	-0.487	-1.986	.003	.029	3	2
UCEC	eIF4G →	+0.307	+3.459	.007	.005	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.531	+1.594	.004	.042	3	1
UCEC	MEK1 →	+0.443	+2.502	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

mTOR by CHI3L1 expression — UCEC

Explore this box plot interactively →