CHI3L1

Across TCGA cell cohorts, CHI3L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,488 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHI3L1-associated GO terms across cancer lineages are Positive regulation of intracellular transport, Positive regulation of cytoplasmic translation, and Establishment of protein localization to endoplasmic reticulum. Each is linked with CHI3L1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CHI3L1-to-partner and partner-to-CHI3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular transport grouped by CHI3L1-low versus CHI3L1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHI3L1→partner) and Y-score (partner→CHI3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of intracellular transport →	+0.075	+5.205	.003	<.001	3	8
LUNG_NSCLC_LUAD	Positive regulation of cytoplasmic translation →	+0.042	+1.327	.007	.001	3	8
BONE	Establishment of protein localization to endoplasmic reticulum →	+0.080	+2.230	.005	.005	3	8
LUNG_NSCLC_LUAD	Negative regulation of glutamate secretion →	+1.279	+1.991	<.001	<.001	3	7
LUNG_NSCLC_LUAD	Macroautophagy →	+0.036	+1.670	.005	.003	3	7
BONE	Endocytic recycling →	+0.064	+2.226	.002	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,488 associations by consensus.

Positive regulation of intracellular transport by CHI3L1 expression — LIVER

Explore this box plot interactively →