CHI3L1

Across TCGA cell cohorts, CHI3L1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible CHI3L1-associated genes across cancer lineages are ACCSL, GJA8, and MRGPRX1. Each is linked with CHI3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHI3L1-to-partner and partner-to-CHI3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACCSL grouped by CHI3L1-low versus CHI3L1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHI3L1→partner) and Y-score (partner→CHI3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ACCSL →	+0.013	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GJA8 →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MRGPRX1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	H1-8 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ODF4 →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	DUSP29 →	+0.040	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ACCSL by CHI3L1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →