CHGA

Across TCGA pan-cancer cohorts, CHGA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CHGA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CHGA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CHGA is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and HNSC are the cancer types where CHGA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHGA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	IV	−3.263	<.001	11	view →
CCRCC	Male	III,IV	−1.521	<.001	8	view →
HNSC	Male	III,IV	−0.933	.001	8	view →
PDAC	All	II,III,IV	−0.888	<.001	8	view →
LSCC	All	All	−0.766	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CHGA–COAD

Open the COAD breakdown →