CHGA

Across TCGA patient cohorts, CHGA protein abundance is significantly associated with the RNA expression of many other genes, with 8,275 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHGA-associated genes across cancer lineages are SYT4, RAB3C, and CHGB. Each is linked with CHGA in more than 3 cancer types. Because this analysis shows association rather than direction, both CHGA-to-partner and partner-to-CHGA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHGA versus SYT4 in GBM, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGA→partner) and Y-score (partner→CHGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYT4 →	+1.586	+1.017	<.001	<.001	3	4
GBM	RAB3C →	+1.542	+0.983	<.001	<.001	3	4
PDAC	CHGB →	+2.079	+0.910	<.001	<.001	3	4
GBM	STMN2 →	+2.397	+1.112	<.001	<.001	3	3
GBM	GABRG2 →	+1.220	+1.052	<.001	<.001	3	3
GBM	TGFBI →	-1.584	-0.919	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,275 associations by consensus.

CHGA vs SYT4 — GBM

Explore this scatter interactively →