CHGA

Across TCGA patient cohorts, CHGA mutation is significantly associated with the RNA expression of many other genes, with 1,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHGA-associated genes across cancer lineages are MIR6894, RNU6-973P, and CBARP. Each is linked with CHGA in more than 1 cancer types. Because this analysis shows association rather than direction, both CHGA-to-partner and partner-to-CHGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6894 grouped by CHGA-low versus CHGA-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGA→partner) and Y-score (partner→CHGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6894 →	+0.561	+5.506	<.001	.005	3	2
SKCM	RNU6-973P →	+0.194	+3.242	<.001	.008	3	2
UCEC	CBARP →	+0.776	+3.708	<.001	<.001	3	2
CESC	LINC02789 →	+0.011	+5.144	<.001	.003	3	2
COAD	OR11H6 →	+0.070	+5.020	<.001	<.001	3	2
SKCM	MAPK10-AS1 →	+0.222	+4.137	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,207 associations by consensus.

MIR6894 by CHGA expression — BRCA

Explore this box plot interactively →