CHGA

Across TCGA patient cohorts, CHGA mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHGA-associated genes across cancer lineages are IGFBP2, Notch1, and p62 Lck ligand. Each is linked with CHGA in more than 1 cancer types. Because this analysis shows association rather than direction, both CHGA-to-partner and partner-to-CHGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by CHGA-low versus CHGA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGA→partner) and Y-score (partner→CHGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.596	-2.584	.049	.011	3	1
UCEC	Notch1 →	+0.192	+1.750	.003	.049	3	1
UCEC	p62 Lck ligand →	+0.439	+3.700	.003	.001	3	1
UCEC	p70-S6K →	+0.196	+1.901	.029	.031	3	1
UCEC	PRDX1 →	+0.197	+3.000	.039	.036	3	1
UCEC	Annexin-1 →	+0.593	+3.019	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IGFBP2 by CHGA expression — UCEC

Explore this box plot interactively →