CHGA

Across TCGA cell cohorts, CHGA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,622 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CHGA-associated GO terms across cancer lineages are Regulation of protein localization to centrosome, Negative regulation of gene expression, epigenetic, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with CHGA in more than 8 cancer types. Because this analysis shows association rather than direction, both CHGA-to-partner and partner-to-CHGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to centrosome grouped by CHGA-low versus CHGA-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHGA→partner) and Y-score (partner→CHGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of protein localization to centrosome →	+0.077	+0.323	<.001	.005	3	9
OVARY	Negative regulation of gene expression, epigenetic →	+0.068	+1.168	<.001	<.001	3	8
SOFT_TISSUE	Negative regulation of mRNA splicing, via spliceosome →	+0.080	+0.208	.001	<.001	2	9
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.123	+3.965	<.001	<.001	3	8
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.135	+4.354	<.001	<.001	3	8
BLOOD_Lymphoma	Nucleic acid catabolic process →	+0.052	+0.160	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,622 associations by consensus.

Regulation of protein localization to centrosome by CHGA expression — SOFT_TISSUE

Explore this box plot interactively →