CHFR

Across TCGA pan-cancer cohorts, CHFR mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CHFR data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CHFR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CHFR expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where CHFR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.439	.006	8	view →
PDAC	OS	Median	III,IV	0.886	0.451	.022	4	view →
HNSC	DFS	Quartile	II,III,IV	0.982	0.872	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CHFR–UCEC (DFS)

Open the UCEC breakdown →