CHERP

Across TCGA pan-cancer cohorts, CHERP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CHERP data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHERP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CHERP expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and GBM are the cancer types where CHERP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.806	0.949	.001	56	view →
LUAD	OS	Median	III,IV	0.775	0.217	.003	20	view →
GBM	OS	Tertile	All	0.540	0.299	.008	14	view →
PDAC	DFS	Tertile	III,IV	0.432	0.817	.017	6	view →
LSCC	DFS	Tertile	II,III,IV	0.869	0.589	.027	6	view →
CCRCC	OS	Quartile	All	0.914	1.000	.032	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CHERP–HNSC (OS)

Open the HNSC breakdown →