CHEK2P2

Mutation & survival
SurvivalMutationKaplan–Meier · TCGA cohorts

Across TCGA pan-cancer cohorts, CHEK2P2 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated CHEK2P2 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher CHEK2P2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CHEK2P2 expression acts as an unfavorable survival marker.

READ are the cancer types where CHEK2P2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.
LineageMeasureSplitStageAUC1
high
AUC2
low
pSampling consensus
READOSMedianII,III,IV0.1870.653.0306view →
Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

CHEK2P2–READ (OS)

Kaplan–Meier survival curve for CHEK2P2 mutant vs wild-type samples in READ.

Open the READ breakdown →

Exploration