CHEK2

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CHEK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,446 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHEK2-associated proteins across cancer lineages are HAT1, RIF1_S782, and RRM2. Each is linked with CHEK2 in more than 9 cancer types. Because this analysis shows association rather than direction, both CHEK2-to-partner and partner-to-CHEK2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK2→partner) and Y-score (partner→CHEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCHAT1 →+0.478+0.828<.001<.001310
PDACRIF1_S782 →+0.954+0.510<.001<.00139
LUADRRM2 →+0.781+0.605<.001<.00139
LUADRRM2_S20 →+1.164+0.550<.001<.00139
BRCARRP36_S73 →+0.897+0.645<.001<.00139
UCECSMC2 →+0.722+0.742<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 23,446 associations by consensus.

Exploration