Across TCGA patient cohorts, CHEK2 protein abundance is significantly associated with the RNA expression of many other genes, with 16,507 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHEK2-associated genes across cancer lineages are TRIP13, MYBL2, and ASF1B. Each is linked with CHEK2 in more than 8 cancer types. Because this analysis shows association rather than direction, both CHEK2-to-partner and partner-to-CHEK2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK2→partner) and Y-score (partner→CHEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIP13 →	+1.016	+0.503	<.001	<.001	3	9
UCEC	MYBL2 →	+1.447	+0.591	<.001	<.001	3	8
HNSC	ASF1B →	+1.081	+0.422	<.001	<.001	3	8
UCEC	RAD51AP1 →	+1.142	+0.547	<.001	<.001	3	8
BRCA	CDCA3 →	+0.975	+0.444	<.001	<.001	3	8
BRCA	CENPA →	+1.177	+0.492	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,507 associations by consensus.

Exploration

CHEK2 survival (RNA) · tumor vs normal (RNA) · all CHEK2 data types