Across TCGA patient cohorts, CHEK2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHEK2-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and STAT3_pY705. Each is linked with CHEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHEK2-to-partner and partner-to-CHEK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK2→partner) and Y-score (partner→CHEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.155	+1.662	.037	.011	3	2
UCEC	p62 Lck ligand →	+0.250	+1.817	.029	.015	3	2
UCEC	STAT3_pY705 →	-0.506	-2.392	<.001	<.001	3	2
UCEC	ASNS →	+0.318	+2.584	.012	.010	3	2
UCEC	ATM →	-0.652	-2.906	<.001	.001	3	2
UCEC	C-Raf →	+0.149	+1.678	.003	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

CHEK2 survival (RNA) · tumor vs normal (RNA) · all CHEK2 data types