Across TCGA cell cohorts, CHEK2 mutation is significantly associated with the RNA expression of many other genes, with 1,067 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHEK2-associated genes across cancer lineages are LCE3D, CNR2, and C9orf92. Each is linked with CHEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHEK2-to-partner and partner-to-CHEK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK2→partner) and Y-score (partner→CHEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LCE3D →	+0.695	+4.222	<.001	.007	3	1
SOFT_TISSUE	CNR2 →	+0.018	+4.548	<.001	.002	2	2
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
SKIN	OR2K2 →	+0.075	+4.977	<.001	.007	3	1
SKIN	OR11H6 →	+0.025	+4.977	<.001	.007	3	1
SKIN	AADACL3 →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,067 associations by consensus.

Exploration

CHEK2 survival (RNA) · tumor vs normal (RNA) · all CHEK2 data types