CHEK1

Across TCGA patient cohorts, CHEK1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHEK1-associated genes across cancer lineages are C-Raf, Cyclin-B1, and ER-alpha. Each is linked with CHEK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHEK1-to-partner and partner-to-CHEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by CHEK1-low versus CHEK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK1→partner) and Y-score (partner→CHEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.132	+2.115	.035	.019	3	3
UCEC	Cyclin-B1 →	+0.678	+2.115	.005	.019	3	2
UCEC	ER-alpha →	+0.852	+2.321	.017	.034	3	1
UCEC	ACC1 →	+0.348	+2.183	.028	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-3.169	.015	.019	3	1
UCEC	Notch1 →	+0.130	+2.115	.035	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C-Raf by CHEK1 expression — UCEC

Explore this box plot interactively →