CHEK1

Across TCGA cell cohorts, CHEK1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHEK1-associated genes across cancer lineages are NTSR2, FAM205A, and NEXMIF. Each is linked with CHEK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CHEK1-to-partner and partner-to-CHEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTSR2 grouped by CHEK1-low versus CHEK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHEK1→partner) and Y-score (partner→CHEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NTSR2 →	+0.082	+3.793	<.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.319	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

NTSR2 by CHEK1 expression — LARGE_INTESTINE

Explore this box plot interactively →