CHD9

Across TCGA patient cohorts, CHD9 mutation is significantly associated with the RNA expression of many other genes, with 6,859 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD9-associated genes across cancer lineages are CDC45, UQCRH, and CDKN3. Each is linked with CHD9 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHD9-to-partner and partner-to-CHD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC45 grouped by CHD9-low versus CHD9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD9→partner) and Y-score (partner→CHD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDC45 →	+0.740	+2.093	<.001	.003	3	6
UCEC	UQCRH →	+0.702	+1.513	<.001	<.001	3	6
SKCM	CDKN3 →	+0.690	+3.719	<.001	<.001	3	6
SKCM	ASF1B →	+0.725	+3.816	<.001	<.001	3	6
SKCM	UBE2S →	+0.628	+3.484	<.001	.002	3	6
UCEC	GINS2 →	+0.801	+1.790	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,859 associations by consensus.

CDC45 by CHD9 expression — SKCM

Explore this box plot interactively →