CHD9

Across TCGA patient cohorts, CHD9 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD9-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Cyclin-B1. Each is linked with CHD9 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD9-to-partner and partner-to-CHD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHD9-low versus CHD9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD9→partner) and Y-score (partner→CHD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.874	+2.008	.006	.018	3	4
UCEC	ATM →	-0.516	-1.440	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.614	+1.898	<.001	<.001	3	3
COAD	MIG-6 →	+0.083	+2.760	.038	.002	3	3
UCEC	Notch1 →	+0.140	+1.440	<.001	<.001	3	3
UCEC	ASNS →	+0.356	+1.415	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by CHD9 expression — COAD

Explore this box plot interactively →