CHD9

Across TCGA cell cohorts, CHD9 mutation is significantly associated with the RNA expression of many other genes, with 1,875 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD9-associated genes across cancer lineages are ZWILCH, SOD2, and AUNIP. Each is linked with CHD9 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD9-to-partner and partner-to-CHD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWILCH grouped by CHD9-low versus CHD9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD9→partner) and Y-score (partner→CHD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZWILCH →	+0.435	+1.807	.001	.005	3	4
BLOOD_Lymphoma	SOD2 →	+0.854	+3.074	.003	.008	3	3
LARGE_INTESTINE	AUNIP →	+0.515	+2.764	<.001	<.001	3	3
LARGE_INTESTINE	HOOK1 →	+0.754	+2.787	.002	<.001	3	3
LARGE_INTESTINE	MMS22L →	+0.846	+2.299	<.001	<.001	3	3
KIDNEY	SCGB3A1 →	+0.077	+3.491	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,875 associations by consensus.

ZWILCH by CHD9 expression — LARGE_INTESTINE

Explore this box plot interactively →