CHD9

Across TCGA cell cohorts, CHD9 mutation is significantly associated with the mutation status of many other genes, with 5,311 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD9-associated genes across cancer lineages are COL22A1, IGFN1, and MDN1. Each is linked with CHD9 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHD9-to-partner and partner-to-CHD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL22A1 grouped by CHD9-low versus CHD9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD9→partner) and Y-score (partner→CHD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COL22A1 →	+1.820	+1.752	.004	.004	1	6
KIDNEY	IGFN1 →	+2.389	+3.184	.003	.003	1	5
LARGE_INTESTINE	MDN1 →	+2.321	+2.974	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	APAF1 →	+3.906	+3.608	.004	.004	1	5
LARGE_INTESTINE	SCAF1 →	+2.415	+2.184	<.001	<.001	1	5
LARGE_INTESTINE	SEC24B →	+2.263	+1.693	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,311 associations by consensus.

COL22A1 by CHD9 expression — BLOOD_Leukemia

Explore this box plot interactively →