CHD8

Across TCGA patient cohorts, CHD8 protein abundance is significantly associated with the RNA expression of many other genes, with 11,461 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHD8-associated genes across cancer lineages are FOXM1, PARP2, and PSMB5. Each is linked with CHD8 in more than 6 cancer types. Because this analysis shows association rather than direction, both CHD8-to-partner and partner-to-CHD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHD8 versus FOXM1 in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD8→partner) and Y-score (partner→CHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXM1 →	+1.134	+0.237	<.001	<.001	3	7
LSCC	PARP2 →	+0.632	+0.338	<.001	<.001	3	7
HNSC	PSMB5 →	+0.929	+0.183	<.001	<.001	3	6
BRCA	STMN1 →	+0.793	+0.217	.001	<.001	3	6
LSCC	NGDN →	+0.592	+0.298	<.001	<.001	3	6
LUAD	NEDD8 →	+0.527	+0.261	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,461 associations by consensus.

CHD8 vs FOXM1 — BRCA

Explore this scatter interactively →