CHD8

Across TCGA patient cohorts, CHD8 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD8-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and Di-Ras3. Each is linked with CHD8 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHD8-to-partner and partner-to-CHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHD8-low versus CHD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD8→partner) and Y-score (partner→CHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.400	+1.292	.005	.004	3	5
STAD	ASNS →	+0.562	+3.000	.006	.034	3	4
BLCA	Di-Ras3 →	-0.171	-3.156	.005	.018	2	5
LUSC	p27_pT198 →	+0.134	+3.000	.038	.033	3	3
LUSC	p38-MAPK_pT180_Y182 →	-0.408	-2.450	.011	.019	3	3
BLCA	c-Met →	-0.189	-3.584	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

Caspase-7-cleavedD198 by CHD8 expression — UCEC

Explore this box plot interactively →