CHD8

Across TCGA cell cohorts, CHD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,718 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHD8-associated GO terms across cancer lineages are Heterochromatin formation, Epigenetic regulation of gene expression, and Negative regulation of gene expression, epigenetic. Each is linked with CHD8 in more than 18 cancer types. Because this analysis shows association rather than direction, both CHD8-to-partner and partner-to-CHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin formation grouped by CHD8-low versus CHD8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD8→partner) and Y-score (partner→CHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Heterochromatin formation →	+0.090	+0.761	<.001	.003	3	19
STOMACH	Epigenetic regulation of gene expression →	+0.084	+0.861	<.001	.001	3	19
STOMACH	Negative regulation of gene expression, epigenetic →	+0.087	+0.698	.001	.005	2	19
OESOPHAGUS	Nuclear export →	+0.111	+0.921	<.001	<.001	3	18
BONE	RNA export from nucleus →	+0.141	+0.668	<.001	.003	2	19
STOMACH	Heterochromatin organization →	+0.090	+0.864	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,718 associations by consensus.

Heterochromatin formation by CHD8 expression — STOMACH

Explore this box plot interactively →