CHD8

Across TCGA cell cohorts, CHD8 mutation is significantly associated with the RNA expression of many other genes, with 2,196 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD8-associated genes across cancer lineages are CASTOR1, BBS7, and NUP54. Each is linked with CHD8 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD8-to-partner and partner-to-CHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASTOR1 grouped by CHD8-low versus CHD8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD8→partner) and Y-score (partner→CHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CASTOR1 →	+0.765	+2.404	<.001	.004	3	4
LARGE_INTESTINE	BBS7 →	+0.635	+2.545	<.001	<.001	3	3
LARGE_INTESTINE	NUP54 →	+0.543	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	WDFY3 →	+0.675	+3.321	<.001	.002	3	3
LARGE_INTESTINE	TET2 →	+0.692	+1.628	.001	.007	3	3
LARGE_INTESTINE	EIF1AX →	+0.456	+3.252	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,196 associations by consensus.

CASTOR1 by CHD8 expression — LARGE_INTESTINE

Explore this box plot interactively →