CHD7

Across TCGA patient cohorts, CHD7 mutation is significantly associated with the RNA expression of many other genes, with 7,873 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD7-associated genes across cancer lineages are NUSAP1, PSMC3IP, and KIF18B. Each is linked with CHD7 in more than 5 cancer types. Because this analysis shows association rather than direction, both CHD7-to-partner and partner-to-CHD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUSAP1 grouped by CHD7-low versus CHD7-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD7→partner) and Y-score (partner→CHD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NUSAP1 →	+0.748	+2.597	.001	.005	3	6
COAD	PSMC3IP →	+0.545	+2.164	<.001	<.001	3	6
UCEC	KIF18B →	+0.544	+1.314	<.001	<.001	3	6
UCEC	RAD51 →	+0.642	+1.406	<.001	<.001	3	5
COAD	TIPIN →	+0.584	+4.100	<.001	<.001	3	5
UCEC	MCM10 →	+0.495	+1.914	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,873 associations by consensus.

NUSAP1 by CHD7 expression — STAD

Explore this box plot interactively →