CHD7

Across TCGA patient cohorts, CHD7 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD7-associated genes across cancer lineages are Cyclin-E2, Cyclin-B1, and eIF4E. Each is linked with CHD7 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHD7-to-partner and partner-to-CHD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CHD7-low versus CHD7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD7→partner) and Y-score (partner→CHD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.154	+2.832	.040	.001	3	5
UCEC	Cyclin-B1 →	+0.497	+2.263	<.001	<.001	3	4
COAD	eIF4E →	+0.153	+2.000	.008	.027	3	4
COAD	4E-BP1 →	+0.171	+3.321	.016	.009	3	4
LUAD	p90 RSK_pT359_S363 →	-0.173	-3.169	.014	.018	3	3
COAD	PCNA →	+0.294	+2.330	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Cyclin-E2 by CHD7 expression — COAD

Explore this box plot interactively →