CHD7

Across TCGA cell cohorts, CHD7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,169 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CHD7-associated GO terms across cancer lineages are Regulation of mRNA stability, RNA polymerase II promoter clearance, and Regulation of growth hormone secretion. Each is linked with CHD7 in more than 14 cancer types. Because this analysis shows association rather than direction, both CHD7-to-partner and partner-to-CHD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA stability grouped by CHD7-low versus CHD7-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD7→partner) and Y-score (partner→CHD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA stability →	+0.056	+1.002	<.001	<.001	3	15
SOFT_TISSUE	RNA polymerase II promoter clearance →	+0.102	+1.531	<.001	<.001	3	14
LIVER	Regulation of growth hormone secretion →	+0.204	+1.304	<.001	<.001	3	14
LIVER	Regulation of DNA repair →	+0.082	+1.736	<.001	<.001	3	14
SOFT_TISSUE	RNA catabolic process →	+0.047	+1.800	<.001	.001	3	14
BONE	mRNA alternative polyadenylation →	+0.080	+1.310	.004	.008	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,169 associations by consensus.

Regulation of mRNA stability by CHD7 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →