CHD5

Across TCGA patient cohorts, CHD5 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD5-associated genes across cancer lineages are Caspase-7-cleavedD198, TFRC, and DJ-1. Each is linked with CHD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both CHD5-to-partner and partner-to-CHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CHD5-low versus CHD5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD5→partner) and Y-score (partner→CHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.810	+1.511	.001	.018	3	5
LUAD	TFRC →	+0.723	+1.678	<.001	.022	3	4
LUAD	DJ-1 →	+0.167	+2.087	.020	.005	3	4
SKCM	YAP_pS127 →	-0.205	-1.807	.049	.003	3	4
STAD	c-Kit →	-0.314	-2.000	.014	.030	3	3
UCEC	4E-BP1 →	+0.286	+1.440	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Caspase-7-cleavedD198 by CHD5 expression — COAD

Explore this box plot interactively →