CHD5

Across TCGA cell cohorts, CHD5 mutation is significantly associated with the RNA expression of many other genes, with 1,815 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD5-associated genes across cancer lineages are ACVR2B, METTL4, and ACYP1. Each is linked with CHD5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD5-to-partner and partner-to-CHD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVR2B grouped by CHD5-low versus CHD5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD5→partner) and Y-score (partner→CHD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACVR2B →	+0.492	+1.808	.001	.001	3	3
LARGE_INTESTINE	METTL4 →	+0.645	+2.212	<.001	<.001	3	3
BLOOD_Leukemia	ACYP1 →	+0.713	+2.614	<.001	.003	3	3
BLOOD_Leukemia	AOC2 →	+0.514	+3.214	.001	.006	3	3
BLOOD_Leukemia	FBXO21 →	+0.854	+3.321	.005	.005	3	3
BLOOD_Leukemia	VARS2 →	+0.614	+3.518	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,815 associations by consensus.

ACVR2B by CHD5 expression — LARGE_INTESTINE

Explore this box plot interactively →