CHD4

Across TCGA patient cohorts, CHD4 protein abundance is significantly associated with the RNA expression of many other genes, with 19,491 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CHD4-associated genes across cancer lineages are KIF15, NDC1, and MSH2. Each is linked with CHD4 in more than 7 cancer types. Because this analysis shows association rather than direction, both CHD4-to-partner and partner-to-CHD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHD4 versus KIF15 in HNSC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD4→partner) and Y-score (partner→CHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KIF15 →	+1.039	+0.239	<.001	<.001	3	8
HNSC	NDC1 →	+0.654	+0.240	<.001	<.001	3	8
HNSC	MSH2 →	+0.811	+0.244	<.001	<.001	3	8
BRCA	CCNB1IP1 →	+0.822	+0.244	<.001	<.001	3	7
HNSC	RAD51AP1 →	+1.092	+0.289	<.001	<.001	3	7
LSCC	RFC5 →	+0.820	+0.233	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,491 associations by consensus.

CHD4 vs KIF15 — HNSC

Explore this scatter interactively →