CHD4

Across TCGA patient cohorts, CHD4 protein abundance is significantly associated with the protein abundance of many other proteins, with 32,361 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CHD4-associated proteins across cancer lineages are SF3B6, SMC1A, and SMNDC1. Each is linked with CHD4 in more than 9 cancer types. Because this analysis shows association rather than direction, both CHD4-to-partner and partner-to-CHD4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CHD4 versus SF3B6 in GBM, with a Pearson correlation of 0.71.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD4→partner) and Y-score (partner→CHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B6 →	+0.309	+0.332	<.001	<.001	3	10
GBM	SMC1A →	+0.338	+0.350	<.001	<.001	3	10
GBM	SMNDC1 →	+0.318	+0.307	<.001	<.001	3	10
LSCC	SNRNP200 →	+0.311	+0.327	<.001	<.001	3	10
GBM	SNRPA1 →	+0.314	+0.343	<.001	<.001	3	10
GBM	U2AF2 →	+0.286	+0.340	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 32,361 associations by consensus.

CHD4 vs SF3B6 — GBM

Explore this scatter interactively →