CHD4

Across TCGA patient cohorts, CHD4 mutation is significantly associated with the RNA expression of many other genes, with 6,242 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD4-associated genes across cancer lineages are INO80C, NXPH4, and BCL2A1. Each is linked with CHD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD4-to-partner and partner-to-CHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INO80C grouped by CHD4-low versus CHD4-high in UCS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD4→partner) and Y-score (partner→CHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	INO80C →	+0.525	+3.078	.003	.007	3	4
UCS	NXPH4 →	+1.598	+3.169	<.001	.007	3	4
SKCM	BCL2A1 →	+1.146	+1.813	<.001	<.001	3	4
LUAD	RNU5A-4P →	+0.357	+2.842	<.001	.002	3	4
UCEC	LONP1 →	+0.243	+1.192	.002	.001	3	4
UCEC	MRPL42 →	+0.204	+0.684	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,242 associations by consensus.

INO80C by CHD4 expression — UCS

Explore this box plot interactively →