CHD4

Across TCGA cell cohorts, CHD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,432 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CHD4-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Regulation of DNA-templated transcription elongation. Each is linked with CHD4 in more than 19 cancer types. Because this analysis shows association rather than direction, both CHD4-to-partner and partner-to-CHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by CHD4-low versus CHD4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD4→partner) and Y-score (partner→CHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.087	+0.670	<.001	.001	3	20
STOMACH	Negative regulation of gene expression, epigenetic →	+0.097	+0.848	<.001	<.001	3	19
BLOOD_Lymphoma	Regulation of DNA-templated transcription elongation →	+0.070	+0.895	<.001	<.001	3	17
BONE	Nucleic acid transport →	+0.092	+0.537	.001	.001	3	17
BONE	RNA transport →	+0.092	+0.537	.001	.001	3	17
SOFT_TISSUE	Nuclear export →	+0.088	+0.955	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,432 associations by consensus.

Epigenetic regulation of gene expression by CHD4 expression — BONE

Explore this box plot interactively →