CHD4

Across TCGA cell cohorts, CHD4 mutation is significantly associated with the RNA expression of many other genes, with 429 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CHD4-associated genes across cancer lineages are CFAP97D2, CLLU1-AS1, and CBY1. Each is linked with CHD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CHD4-to-partner and partner-to-CHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFAP97D2 grouped by CHD4-low versus CHD4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD4→partner) and Y-score (partner→CHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CFAP97D2 →	+0.043	+5.087	<.001	.004	3	3
URINARY_TRACT	CLLU1-AS1 →	+0.113	+5.087	<.001	.004	3	2
LARGE_INTESTINE	CBY1 →	+0.516	+2.244	.002	.003	3	2
LARGE_INTESTINE	BNIP1 →	+0.400	+2.389	.001	.006	3	2
LARGE_INTESTINE	IQCG →	+0.928	+3.459	<.001	.001	3	2
LARGE_INTESTINE	GOT1 →	+0.522	+3.321	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 429 associations by consensus.

CFAP97D2 by CHD4 expression — URINARY_TRACT

Explore this box plot interactively →