CHD2

Across TCGA patient cohorts, CHD2 mutation is significantly associated with the RNA expression of many other genes, with 7,424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CHD2-associated genes across cancer lineages are ZFP3, CFTRP1, and EWSR1. Each is linked with CHD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CHD2-to-partner and partner-to-CHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZFP3 grouped by CHD2-low versus CHD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CHD2→partner) and Y-score (partner→CHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZFP3 →	-0.465	-1.304	.001	<.001	3	4
BLCA	CFTRP1 →	+0.078	+3.273	.005	.004	3	4
UCEC	EWSR1 →	+0.321	+1.695	<.001	<.001	3	3
UCEC	DDX41 →	+0.263	+1.595	<.001	<.001	3	3
UCEC	EMID1 →	-0.845	-2.311	<.001	<.001	3	3
UCEC	FANCA →	+0.729	+2.292	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,424 associations by consensus.

ZFP3 by CHD2 expression — UCEC

Explore this box plot interactively →